A latest article of EMBO J showing the role of ecdysone signalling in the regulation of female Drosophila GSC niche size.
It is interesting to see another related research about ecdysone and GSC control (link).
EMBO J. 2011 Mar 18. [Epub ahead of print]
Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation.
König A, Yatsenko AS, Weiss M, Shcherbata HR.
Max Planck Research Group of Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Abstract
Previously, it has been shown that in Drosophila steroid hormones are required for progression of oogenesis during late stages of egg maturation. Here, we show that ecdysteroids regulate progression through the early steps of germ cell lineage. Upon ecdysone signalling deficit germline stem cell progeny delay to switch on a differentiation programme. This differentiation impediment is associated with reduced TGF-β signalling in the germline and increased levels of cell adhesion complexes and cytoskeletal proteins in somatic escort cells. A co-activator of the ecdysone receptor, Taiman is the spatially restricted regulator of the ecdysone signalling pathway in soma. Additionally, when ecdysone signalling is perturbed during the process of somatic stem cell niche establishment enlarged functional niches able to host additional stem cells are formed.
PMID: 21423150 [PubMed - as supplied by publisher]
Incoming search terms:
- drosophila germline stem cell niche formation
- drosophila germline stem cells cancer
- ecdysone regulation in stem cells in drosophila
- germline stem cell niche
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