Gene Dog Blog

The prostate: cancer prevalence

The prostate is a doughnut-shaped composite organ apart of the male reproductive system which is located under the bladder, and in front of the bowel.  The prostate stores and secretes an alkaline fluid consisting of semen (20%-30%), spermatazoa, and seminal vesicle fluid.  Spermatazoa expelled in prostatic fluid have better motility, longer survival and better protection over DNA than that expelled with seminal vesicular fluid.

According to the Prostate Cancer Foundation, prostate cancer is the most common cancer in America not relative to the skin, with breast cancer (also relative to high estrogen) effecting women in almost equal numbers.

Estrogen

Prior to the 21st century, estrogen was considered a carcinogen.  Both recent and older studies have evidence against estrogen as a contributor to inflammation, disease, and cancer.  Certain researchers and endocrinologists, such as Ray Peat, Ph.D. agree with pre-21st century assessment, as Peat states the following,

“In good health, an animal’s systems are designed so that certain tissues will be intensely but briefly stimulated by estrogen. This stimulation by estrogen doesn’t produce the normal amount of carbon dioxide, so the tissue experiences oxygen deprivation, leading to swelling and cell division. (Along with the reduced carbon dioxide production, there is increased lipid peroxidation). Any similar stimulation, whether it’s produced by soot, or suffocation, or irradiation, will produce the broad range of estrogen’s effects, beginning with inflammation but ending with atrophy or cancer if it is too prolonged.”

Evidence: link between prostate cancer and estrogen

In the Journal of Cellular Biochemistry (Volume 102, Issue 4), Giuseppe Carruba produced an article entitled “Estrogen and prostate cancer: An eclipsed truth in an androgen-dominated scenario” (pages 899-911, 1 November 2007)  In the abstract, he explains that prostate cancer in humans is generally considered a paradigm of androgen-dependent tumor, but that estrogen’s role in the prostate is equally as important.  He explains the same accumulation of steroid derivatives with distinct biological activities occurs similarly in hydroxylated estrogens in the human breast.  He goes on to state that there is long-term evidence that administration of estrogens and androgens combined create prostate cancer in rats.  He concludes that estrogen plays a critical role in prostate cancer, and should be more considered than androgens alone.

Causes of raised estrogen

Radiation, birth control, stress, gut inflammation/irritation, unsaturated oils and hypothyroidism all commonly contribute to high amounts of the hormone estrogen.  Obviously in males, they should not worry about a contraceptive pill.  However, the diet of Americans is extremely high in unsaturated oils (popular in almost all restaurants, fast food chains, and processed foods), as well as additives and allergens which contribute to digestive disruption.  It’s commonly advocated to strenuously exercise (a form of stress), and reduce levels of salt (reducing progesterone production).  Elevated estrogen in either gender is possible, and with the evidence of it’s impact on prostate cancer, it seems best to avoid it, and hope for further research.

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Bio:
Chloe Trogden specializes in research involving all forms of college grants. She has compiled thousands of resources including private school grants and Washington DC college grants along with many others. She is currently attending UNC Chapel Hill and is entering her Junior year in the fall.

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